CPython is the safe default. PyPy can be 5-10x faster on long-running pure-Python loops, but libraries with C extensions (numpy, pandas, anything with binary wheels) usually don’t run on PyPy. CPython 3.13 has a JIT in experimental builds. For AI work, optimize the I/O + LLM call first; swap Python implementation last.
PyPy wins on long-running pure-Python loops with no C extension.
CPython 3.13 JIT: still experimental; risks subtle numerical differences.
For ML apps, most time is in C extensions or LLM network calls. Optimize those first.
Profile before you switch interpreter.
long pure-Python loop -> PyPy 5-10x
numerical/ML libs -> CPython (binary wheels)
CPU warmups matter more in practice
Switch Python implementations LAST. Profile and optimize the actual bottleneck first.